Карточка-задание по английскому языку на тему «MEDICAL WRITING: CASE ABSTRACT_143»
«MEDICAL WRITING: CASE ABSTRACT_143»
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·What parts does it include?
·What is an abstract?
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Osteonecrosis of the jaw as
a possible rare side effect of annual bisphosphonate administration for
osteoporosis: A case report
Osteonecrosis of the jaw is a
serious side effect in patients receiving nitrogen-containing bisphosphonates
intravenously due to malignant diseases. Albeit far less frequently,
osteonecrosis of the jaw has also been reported to occur due to the oral
administration of nitrogen-containing bisphosphonates due to osteoporosis.
Annual infusions of zoledronic acid have been recommended in order to improve
patient compliance, to optimize therapeutic effects and to minimize side
effects. To date, osteonecrosis of the jaw has not been linked to the annual
administration of bisphosphonates.
We report the case of a
65-year-old Caucasian woman suffering from osteoporosis who developed early
stage osteonecrosis of the jaw in two locations, with chronic infections, after
two months of oral bisphosphonate treatment and three annual administrations of
zoledronic acid. Our patient was treated by fluorescence-guided resection of
the necrotic jaw bone areas; local inflammation was treated by removal of a
wisdom tooth and repeat root resections. Histopathology revealed typical
hallmarks of osteonecrosis of the jaw.
Osteonecrosis of the jaw may occur
as a consequence of annual administrations of zoledronic acid. It is
conceivable that, due to the pharmacological properties of bisphosphonates, a
jaw bone that encounters frequent local inflammations is more likely to develop
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1.Is this the first report of this kind in the literature?
2.What are brief details of what the patient(s) presented with?
3.What the reader should learn from the case report?
4.What the clinical impact will be?
5.Is it an original case report of interest to a particular clinical
specialty of medicine?
6.Will it have a broader clinical impact across medicine?
7.Are any teaching points identified?
·Why abstract is the most important part for case
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