Карточка-задание по английскому языку на тему «MEDICAL WRITING: CASE ABSTRACT_34»
«MEDICAL WRITING: CASE ABSTRACT_34»
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A complicated case of
pachydermoperiostosis with spondyloarthritides: a case report
Pachydermoperiostosis is a rare,
hereditary disease commonly presenting with digital clubbing, pachydermia and
periosteal hypertrophy. Therapeutic options for pachydermoperiostosis are few
because of the unknown pathogenesis. Here, we report the complicated case of a
patient with pachydermoperiostosis combined with spondyloarthritides, who was
refractory to steroids and tumor necrosis factor alpha antagonists. We treated
this patient with zoledronic acid and performed an arthroscopic synovectomy,
with a satisfactory outcome. To the best of our knowledge, this is the first
report in English on the combination of zoledronic acid administration and
synovectomy for the treatment of a patient with pachydermoperiostosis and
An 18-year-old Han Chinese man was
diagnosed with pachydermoperiostosis in the presence of digital clubbing,
periostitis and swollen limbs. Combined spondyloarthritides was also considered
based on his lower back pain, lower limbs synovitis, bilateral sacroiliac
sclerosis and a positive test for human leukocyte antigen B27, as well as
immunoglobulin A nephropathy. He was refractory to steroids and tumor necrosis
factor alpha antagonists, but treated with intravenous zoledronic acid and an
arthroscopic synovectomy, with a satisfactory outcome.
This is a rare, complicated case
of pachydermoperiostosis with spondyloarthritides. Combination therapy of
zoledronic acid administration with synovectomy is a novel, convenient and
effective option for patients with pachydermoperiostosis with remarkable
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