Карточка-задание по английскому языку на тему «MEDICAL WRITING: CASE ABSTRACT_441»
«MEDICAL WRITING: CASE ABSTRACT_441»
·What is a medical case report?
·What parts does it include?
·What is an abstract?
Read the abstract of the medical case
Successful treatment of
metastatic hepatic epithelioid hemangioendothelioma with thalidomide: a case
hemangioendothelioma is a rare malignancy arising from the vascular endothelial
cells within the liver. Historically, the disease is characterized as being
poorly responsive to both chemotherapy and radiotherapy, with liver resection
or transplantation the treatment of choice when feasible. For patients with
advanced disease, reports of long-term therapeutic benefits from conventional
cytotoxic treatments are very limited. Owing to the rarity of this malignancy,
there is no structured therapeutic research, but a small number of cases have
been reported to respond well to treatment with inhibitors of angiogenesis.
Thalidomide was originally developed as an anti-emetic but is a potent
inhibitor of vascular neogenesis, and could offer potential in the treatment of
hepatic epithelioid hemangioendothelioma by blocking the proliferation of the
malignant vascular endothelial cells.
We describe the case of a
Caucasian British woman who presented at the age of 53 years with a hepatic
mass, malignant lymphadenopathy and pulmonary metastases, which were confirmed
as hepatic epithelioid hemangioendothelioma on biopsy. After unproductive
treatment with interferon, our patient was started on thalidomide 400 mg daily.
She has been successfully managed on this therapy for the past seven years, and
has remained asymptomatic, with radiologically stable disease and minimal
treatment-related side effects.
At present, there is no standard
therapy for advanced hepatic epithelioid hemangioendothelioma. Our case
supports the role for thalidomide and potentially other inhibitors of vascular
neogenesis in the treatment of patients with metastatic hepatic epithelioid
Find in the abstract:
·Why is it important
·Needs to be reported
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1.Is this the first report of this kind in the literature?
2.What are brief details of what the patient(s) presented with?
3.What the reader should learn from the case report?
4.What the clinical impact will be?
5.Is it an original case report of interest to a particular clinical
specialty of medicine?
6.Will it have a broader clinical impact across medicine?
7.Are any teaching points identified?
·Why abstract is the most important part for case
published in electronic databases?