Карточка-задание по английскому языку на тему «MEDICAL WRITING: CASE ABSTRACT_375»
«MEDICAL WRITING: CASE ABSTRACT_375»
·What is a medical case report?
·What parts does it include?
·What is an abstract?
Read the abstract of the medical case
Bevacizumab for the
treatment of surgically unresectable cervical cord hemangioblastoma: a case
Hemangioblastomas are highly
vascular tumors that can arise within the central nervous system as well as
other organ systems within the body. They can arise sporadically or as part of
von Hippel-Lindau syndrome. Those arising in critical locations within the
central nervous system can be difficult to resect surgically and therefore pose
a significant challenge and result in morbidity and even mortality.
Hemangioblastomas express high levels of vascular endothelial growth factor
that drives angiogenesis and tumor progression. We hypothesized that
bevacizumab through its inhibitory effect on vascular endothelial growth factor
will result in hemangioblastoma tumor regression as well as a meaningful
We present the case of a
51-year-old Caucasian man with surgically unresectable cervical cord
hemangioblastoma presenting with progressive weakness leading to quadriparesis.
He was treated with bevacizumab and his follow up magnetic resonance imaging
scans showed marked tumor regression. After only six cycles of intravenous
bevacizumab (10mg/kg every two weeks), he started ambulating after being
wheelchair bound. He is currently still receiving treatment almost two years
after initiation of bevacizumab.
We have shown for the first time
that bevacizumab can result in significant tumor regression and a sustained
clinical improvement in a patient with an otherwise unresectable spinal cord
hemangioblastoma. This novel approach can be immensely useful for patients with
difficult to resect hemangioblastomas or those with multiple lesions such as in
von Hippel-Lindau syndrome.
Find in the abstract:
·Why is it important
·Needs to be reported
Answer the questions:
1.Is this the first report of this kind in the literature?
2.What are brief details of what the patient(s) presented with?
3.What the reader should learn from the case report?
4.What the clinical impact will be?
5.Is it an original case report of interest to a particular clinical
specialty of medicine?
6.Will it have a broader clinical impact across medicine?
7.Are any teaching points identified?
·Why abstract is the most important part for case
published in electronic databases?