Карточка-задание по английскому языку на тему «MEDICAL WRITING: CASE ABSTRACT_420»
«MEDICAL WRITING: CASE ABSTRACT_420»
·What is a medical case report?
·What parts does it include?
·What is an abstract?
Read the abstract of the medical case
Late-onset benefit in
progressive advanced hepatocellular carcinoma with continued sorafenib therapy:
a case report
In the past, no effective systemic
therapy has existed for patients with advanced hepatocellular carcinoma.
Sorafenib, an oral multikinase inhibitor, has recently been shown to improve
overall survival in patients with advanced hepatocellular carcinoma in two
randomized, double-blinded, placebo-controlled trials. This drug has been
approved as the first-line therapy for advanced hepatocellular carcinoma
patients. We report an intriguing case of advanced hepatocellular carcinoma in
which the patient achieved late- onset partial response by prolonged
administration of sorafenib in spite of progressive disease.
A 54-year-old Japanese man was
treated with sorafenib for multiple lung metastases after surgical resection
for advanced hepatocellular carcinoma accompanied by vascular invasion of the
left branch of the portal vein. Although the effective diagnosis was
progressive disease, almost all sites began to reduce or disappear eight months
after the diagnosis of progressive disease. A dramatic reduction in
alpha-fetoprotein and des-gamma-carboxy prothrombin levels was observed. The
patient finally achieved partial response and his status remains unchanged.
If tolerated, prolonged sorafenib
treatment may be beneficial.
Find in the abstract:
·Why is it important
·Needs to be reported
Answer the questions:
1.Is this the first report of this kind in the literature?
2.What are brief details of what the patient(s) presented with?
3.What the reader should learn from the case report?
4.What the clinical impact will be?
5.Is it an original case report of interest to a particular clinical
specialty of medicine?
6.Will it have a broader clinical impact across medicine?
7.Are any teaching points identified?
·Why abstract is the most important part for case
published in electronic databases?