Карточка-задание по английскому языку на тему «MEDICAL WRITING: CASE ABSTRACT_452»
«MEDICAL WRITING: CASE ABSTRACT_452»
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as enchondromatosis and ossification of the spinal ligaments: a case report
A girl presented with
achondroplasia manifested as mild knee pain associated with stiffness of her
back. A skeletal survey showed enchondroma-like metaphyseal dysplasia and ossification
of the spinal ligaments. Magnetic resonance imaging of the spine further
clarified the pathological composites.
A 7-year-old girl presented with
the classical phenotypic features of achondroplasia. Radiographic documentation
showed the co-existence of metaphyseal enchondromatosis and development of
spinal bony ankylosis. Magnetic resonance imaging showed extensive ossification
of the anterior and posterior spinal ligaments. Additional features revealed by
magnetic resonance imaging included calcification of the peripheral vertebral
bodies associated with anterior end-plate irregularities.
Enchondromas are metabolically
active and may continue to grow and evolve throughout the patient's lifetime;
thus, progressive calcification over a period of years is not unusual.
Ossification of the spinal ligaments has a specific site of predilection and
often occurs in combination with senile ankylosing vertebral hyperostosis.
Nevertheless, ossification of the spinal ligaments has been encountered in
children with syndromic malformation complex. It is a multifactorial disease in
which complex genetic and environmental factors interact, potentially leading
to chronic pressure on the spinal cord and nerve roots with subsequent
development of myeloradiculopathy. Our patient presented with a combination of
achondroplasia, enchondroma-like metaphyseal dysplasia and calcification of the
spinal ligaments. We suggest that the development of heterotopic bone formation
along the spinal ligaments had occurred through an abnormal ossified enchondral
mechanism. We postulate that ossification of the spinal ligaments and metaphyseal
enchondromatous changes are related to each other and represent impaired
terminal differentiation of chondrocytes in this particular case. Standard
radiographic examination showed spinal bony ankylosis only. The pathological
composites of the vertebrae have been clarified using scanning technology.
Extensive spinal ligament ossification associated with calcification of the
peripheral vertebral bodies and anterior end-plate irregularities were notable.
We report what may be a novel spinal and extraspinal malformation complex in a
girl with achondroplasia.
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