Карточка-задание по английскому языку на тему «MEDICAL WRITING: CASE ABSTRACT_392»
«MEDICAL WRITING: CASE ABSTRACT_392»
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kinase-negative anaplastic large cell lymphoma with extranodal involvement of
the thigh muscle: a case report
Anaplastic large cell lymphoma is
a rare type of non-Hodgkin lymphoma. The most common extranodal sites of
anaplastic large cell lymphoma are skin, subcutaneous tissue, bone, lung, and
gastrointestinal organs. The involvement of the skeletal muscle has been
described rarely in extranodal anaplastic large cell lymphoma.
An 89-year-old Japanese man
visited our hospital with a three-month history of swelling of his left thigh
and slight fever. The swelling had rapidly enlarged and become painful within
the previous three days. Magnetic resonance imaging scans revealed two
soft-tissue tumors in the intramuscular layer between the vastus medialis
muscle and the adductor muscle. Extensive peritumoral inflammatory edema was
obvious. As the results of physical and radiological examinations were highly
suggestive of abscess formation, we prescribed antibiotics for two weeks.
However, our patient’s symptoms did not improve. Therefore, we suspected a
soft-tissue sarcoma, and our patient underwent an incision biopsy. Histological
analysis revealed that the atypical cells were positive for CD3 and CD30 but
negative for anaplastic lymphoma kinase. A computed tomography scan of the
thorax revealed mediastinal lymphadenopathy and bilateral pleural effusions,
suggestive of extranodal involvement of skeletal muscle in anaplastic lymphoma
kinase-negative anaplastic large cell lymphoma. We planned to give our patient
systemic chemotherapy. However, rapid systemic dissemination occurred and our
patient died of multiple organ failure five weeks after his first visit to our
Here, we present a case of
anaplastic lymphoma kinase-negative anaplastic large cell lymphoma with
extranodal involvement in the thigh muscle. The involvement of such a rare
organ may lead to initial misdiagnosis and a delay in the onset of treatment.
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