Карточка-задание по английскому языку на тему «MEDICAL WRITING: CASE ABSTRACT_162»
«MEDICAL WRITING: CASE ABSTRACT_162»
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Acute hepatocellular and
cholestatic injury during therapy with hydrochlorothiazide -
clinicohistopathologic findings: a case report
thiazide-like diuretics are considered first-line drugs for initial therapy in
uncomplicated arterial hypertension. Acute cholecystitis is a well-known
complication during treatment with thiazide, and these drugs are also reported
to be followed by pronounced insulin resistance.
We describe a case of acute
cholestatic hepatitis in a 68-year-old Caucasian man who was receiving
olmesartan and hydrochlorothiazide for arterial hypertension. From the clinical
and histologic findings, we diagnosed him as having hepatocellular-cholestatic
injury and a disorder of glucose metabolism in the liver. To the best of our
knowledge, no histopathologic description of hydrochlorothiazide hepatotoxicity
has previously been documented in the literature.
In the differential diagnosis of
cholestatic hepatitis, clinicians should be aware of the possibility of liver
damage in patients receiving hydrochlorothiazide therapy.
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