Карточка-задание по английскому языку на тему «MEDICAL WRITING: CASE ABSTRACT_194»
«MEDICAL WRITING: CASE ABSTRACT_194»
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·What parts does it include?
·What is an abstract?
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Vitamin B12 deficiency
with combined hematological and neuropsychiatric derangements: a case report
Although vitamin B12 deficiency
is a well-known cause of hematological and neuropsychiatric illness, the
presentation of combined severe pancytopenia, demyelination and prominent psychiatric
impairment is rare.
We present a case of a previously
healthy 55-year-old East African man with severe vitamin B12 deficiency
(serum vitamin B12 22pmol/L) secondary to pernicious anemia. He
had a severe hypoproliferative megaloblastic anemia with hemolysis (hemoglobin
61g/L, mean corpuscular volume 99fL, reticulocytes 0.8%, haptoglobin
undetectable), leukopenia (2.7×109/L), thrombocytopenia
(96×109/L), ataxia with central demyelination, and
megaloblastic madness. The patient’s anemia, myelopathy and psychiatric
condition responded well to parenteral vitamin B12 replacement
therapy, with significant improvement seen within weeks.
Hematological manifestations of
vitamin B12 deficiency are typically inversely correlated with
the presence and severity of neuropsychiatric impairment. Although uncommon, a
presentation with severe hematological and neuropsychiatric disease can occur,
as illustrated by this case. Its presence may help guide diagnosis as well as
provide clinically important prognostic information.
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1.Is this the first report of this kind in the literature?
2.What are brief details of what the patient(s) presented with?
3.What the reader should learn from the case report?
4.What the clinical impact will be?
5.Is it an original case report of interest to a particular clinical
specialty of medicine?
6.Will it have a broader clinical impact across medicine?
7.Are any teaching points identified?
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